POU6F2

Overview

POU6F2 (POU Class 6 Homeobox 2) encodes a POU-domain transcription factor involved in neuronal development. In neuroblastoma, POU6F2 is a defining marker of a novel postnatal human adrenal progenitor cluster (hC1) and is shared with the undifferentiated nC3 cluster enriched in high-risk tumors.

Alterations observed in the corpus

• POU6F2 is a significantly over-expressed marker gene of the novel postnatal human adrenal progenitor cluster hC1 (FDR <0.01, Welch’s t-test on 1,322 nuclei), which is uniquely present in human but not mouse postnatal adrenal gland. The hC1/nC3 shared progenitor gene program includes POU6F2 alongside BCL11A, ERBB3, RTTN, TP63, ASXL3, SOX6, CLDN11, and DOCK7. PMID:34493726

Cancer types (linked)

• NBL — POU6F2 is part of the shared gene signature between the postnatal adrenal hC1 progenitor and the undifferentiated nC3 cluster of high-risk neuroblastoma tumors, supporting the hypothesis that high-risk neuroblastoma may arise from this postnatally restricted progenitor. PMID:34493726

Co-occurrence and mutual exclusivity

• Co-expressed with BCL11A, ERBB3, RTTN, TP63, ASXL3, SOX6, CLDN11, NTRK2 in the hC1/nC3 progenitor compartment; expression is distinct from canonical SCP markers (SOX10, S100B, FOXD3). PMID:34493726

Therapeutic relevance

• No direct targeted therapy is reported in the corpus.

Open questions

• Functional validation of POU6F2 in maintaining the progenitor state in hC1 cells or promoting high-risk neuroblastoma identity is not reported. PMID:34493726

Sources

• PMID:34493726

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