SEC61G
Overview
SEC61G encodes the gamma subunit of the SEC61 translocon complex, which mediates protein translocation across the endoplasmic reticulum membrane. In GBM, SEC61G is located at the 7p11 locus near EGFR and has been identified as a fusion partner in EGFR-locus rearrangements.
Alterations observed in the corpus
- Participates in a SEC61G–EGFR fusion transcript (n=4) in GBM; identified among the 7p11 EGFR-locus fusions detected by RNA-seq in the TCGA GBM comprehensive genomic characterization PMID:24120142
Cancer types (linked)
- GBM — SEC61G–EGFR in-frame fusion identified in 4/164 RNA-seq cases; one of several EGFR-locus fusions at 7p11 PMID:24120142
Co-occurrence and mutual exclusivity
- SEC61G–EGFR fusion occurs in the context of other EGFR-locus rearrangements in GBM (EGFR–SEPT14 in 6 cases, LANCL2–SEPT14 in 1, COBL–SEPT14 in 1) PMID:24120142
Therapeutic relevance
- EGFR-locus fusions including SEC61G–EGFR contribute to the broad EGFR alteration spectrum (57% of GBM); therapeutic targeting is complicated by intratumoral heterogeneity of co-existing EGFR alteration forms PMID:24120142
Open questions
- Whether SEC61G–EGFR fusion produces a functional kinase-active product and whether it responds differentially to EGFR inhibitors compared to other EGFR alteration forms is not established.
Sources
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