VOPP1
Overview
VOPP1 (Vesicular Overexpressed in Cancer Prosurvival Protein 1, also known as ECOP/GASP) maps to chromosome 7p11, immediately adjacent to the EGFR locus. It encodes a transmembrane protein with proposed pro-survival signaling roles. In glioblastoma, VOPP1 falls within the 7p11 amplicon that is frequently co-amplified alongside EGFR, and may be implicated in EGFR-proximal structural rearrangements documented in the TCGA GBM landscape study.
Alterations observed in the corpus
- VOPP1 catalogued as a gene at the 7p11 EGFR locus in the TCGA somatic genomic landscape of GBM; present in the gene list of a cohort with extensive EGFR-locus rearrangements, co-amplifications (SEC61G, LANCL2), and intrachromosomal fusions PMID:24120142.
Cancer types (linked)
- GBM: VOPP1 resides within the chr7p11 amplicon that drives EGFR overexpression in 57% of GBM; specific VOPP1-level alterations are not individually quantified in the TCGA 2013 GBM landscape paper PMID:24120142.
Co-occurrence and mutual exclusivity
- Co-localizes with SEC61G and LANCL2 as genes in the EGFR 7p11 amplicon region; EGFR fusions (EGFR-SEPT14, SEC61G-EGFR, LANCL2-SEPT14) were the primary structural events catalogued at this locus PMID:24120142.
Therapeutic relevance
- No VOPP1-specific therapeutic implications discussed in the corpus; the 7p11 amplicon is the basis for EGFR-targeting strategies in GBM PMID:24120142.
Open questions
- Whether VOPP1 contributes independently to GBM biology beyond its co-localization with EGFR amplification has not been addressed in the corpus PMID:24120142.
Sources
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