IL36A

Overview

IL36A (Interleukin 36 Alpha) is a member of the IL-1 cytokine family involved in inflammatory signaling. In cancer genomics, it has been identified as a candidate tumor suppressor gene with loss-of-function mutations in desmoplastic melanoma.

Alterations observed in the corpus

  • Loss-of-function candidate tumor suppressor identified via high LOF-burden analysis in desmoplastic melanoma; listed among top LOF-burden tumor suppressor candidates alongside FSIP1, CDH2, and PAK3 PMID:26343386

Cancer types (linked)

  • Desmoplastic melanoma: candidate tumor suppressor based on LOF-burden analysis in exome sequencing cohort PMID:26343386

Co-occurrence and mutual exclusivity

  • Co-occurs with other LOF-burden tumor suppressor candidates (FSIP1, CDH2, PAK3) in desmoplastic melanoma; occurs in a tumor context dominated by TERT promoter mutations (90%), CDKN2A deletions (11 cases), and diverse MAPK pathway alterations PMID:26343386

Therapeutic relevance

  • No direct therapeutic targeting reported; the paper identifies IL36A as a candidate tumor suppressor but does not propose specific drug interventions PMID:26343386

Open questions

  • Functional validation of IL36A as a tumor suppressor in desmoplastic melanoma is lacking; LOF-burden designation is statistical and requires experimental confirmation PMID:26343386

Sources

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