FSIP1

Overview

FSIP1 (Fibrous Sheath Interacting Protein 1) is a structural protein primarily associated with sperm flagella. It was identified as a loss-of-function burden candidate tumor suppressor in desmoplastic melanoma.

Alterations observed in the corpus

• Loss-of-function burden candidate tumor suppressor in desmoplastic melanoma (WGS/WES cohort); identified alongside CDH2, IL36A, and PAK3 as LOF candidates PMID:26343386

Cancer types (linked)

• DM (Desmoplastic melanoma): LOF burden candidate in a desmoplastic melanoma WGS cohort PMID:26343386

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26343386

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