DOCK7
Overview
DOCK7 (dedicator of cytokinesis 7) is a guanine nucleotide exchange factor involved in cytoskeletal remodeling and cell migration. In the context of neuroblastoma, DOCK7 is identified as a component of the migratory gene program shared between the novel postnatal human adrenal gland progenitor cluster (hC1) and the undifferentiated, high-risk neuroblastoma cluster (nC3).
Alterations observed in the corpus
- DOCK7 is part of the progenitor/migratory gene program shared between the hC1 postnatal human adrenal progenitor and the high-risk undifferentiated neuroblastoma nC3 cluster; identified as a significantly upregulated marker of hC1 (FDR <0.01, Welch’s t-test) PMID:34493726.
- Co-expression of DOCK7 and CLDN11 in both hC1 and nC3 highlights a migratory/progenitor gene signature distinguishing high-risk tumor identity from low-risk noradrenergic clusters PMID:34493726.
Cancer types (linked)
- NBL — DOCK7 co-expression with CLDN11, ERBB3, NTRK2, and other progenitor genes marks the high-risk undifferentiated nC3 cluster; correlates with poor-prognosis transcriptional identity PMID:34493726.
Co-occurrence and mutual exclusivity
Therapeutic relevance
- Not directly targeted in the corpus; DOCK7 expression in the high-risk nC3 cluster is a transcriptional correlate of unfavorable neuroblastoma identity PMID:34493726.
Open questions
- The functional role of DOCK7-mediated cytoskeletal remodeling in neuroblastoma cell migration and invasion has not been experimentally validated PMID:34493726.
Sources
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