COL22A1
Overview
COL22A1 (collagen type XXII alpha 1 chain) encodes an extracellular matrix protein expressed at tissue junctions. In cancer genomics, COL22A1 was identified as a significantly mutated gene in small cell lung cancer (SCLC) by whole-genome sequencing, though its functional role in SCLC pathogenesis is unclear and requires experimental follow-up.
Alterations observed in the corpus
- Significantly mutated gene in SCLC (110-tumor WGS cohort); included in the group of novel SMGs with unclear biological function (alongside RGS7, FPR1, CRACDL/KIAA1211); authors explicitly note functional role “is much less clear” PMID:26168399
Cancer types (linked)
- SCLC: recurrently mutated in WGS cohort; specific prevalence not quantified separately; categorized as a novel SMG of unclear function PMID:26168399
Co-occurrence and mutual exclusivity
- Co-identified with RGS7, FPR1, and CRACDL as novel significantly mutated genes with unclear function in SCLC PMID:26168399
Therapeutic relevance
- No direct therapeutic associations identified in this corpus.
Open questions
- Functional experiments required to determine whether COL22A1 mutations contribute causally to SCLC pathogenesis or represent passenger events PMID:26168399
Sources
This page was processed by crosslinker on 2026-05-14.