FOXQ1

Overview

FOXQ1 (Forkhead Box Q1) is a forkhead-family transcription factor. In cancer genomics, FOXQ1 has been identified as a significantly mutated gene in muscle-invasive bladder cancer.

Alterations observed in the corpus

• FOXQ1 identified as a significantly mutated gene (SMG) at ≤8% frequency in muscle-invasive bladder cancers in TCGA urothelial carcinoma comprehensive genomic characterization PMID:24476821

Cancer types (linked)

• BLCA: SMG at ≤8% frequency in muscle-invasive urothelial carcinoma PMID:24476821

Co-occurrence and mutual exclusivity

• Co-listed SMG alongside KLF5, PAIP1, ZFP36L1, CCND3, FOXA1, and HRAS in bladder cancer PMID:24476821

Therapeutic relevance

• No direct therapeutic targeting reported in corpus.

Open questions

• Functional significance of FOXQ1 mutations in bladder cancer pathogenesis not yet established PMID:24476821

Sources

• PMID:24476821

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