KLF5

Overview

KLF5 (Kruppel Like Factor 5) is a zinc-finger transcription factor involved in cell proliferation and differentiation. In cancer genomics, KLF5 has been identified as a significantly mutated gene in muscle-invasive bladder cancer.

Alterations observed in the corpus

  • KLF5 identified as a significantly mutated gene (SMG) at ≤8% frequency in muscle-invasive bladder cancers in TCGA urothelial carcinoma comprehensive genomic characterization PMID:24476821
  • Zinc-finger transcription factor regulating intestinal stem-cell niche; identified as a new CRC significantly mutated gene; deletion suppresses CRC oncogenesis (Nakaya et al. 2014) PMID:27149842
  • Recurrently mutated gene identified in the TCGA pan-lung cancer cohort PMID:27158780

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic targeting reported in corpus.

Open questions

  • Functional significance of KLF5 mutations in bladder cancer pathogenesis not yet established PMID:24476821

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:27149842

This page was processed by wiki-cli on 2026-05-14. - PMID:27158780

This page was processed by wiki-cli on 2026-05-14.