KRT17

Overview

KRT17 (Keratin 17) is an intermediate filament protein expressed in the hair follicle, nail bed, and sebaceous glands, and more broadly in basal keratinocytes. It serves as a lineage-confirmation marker for keratinocytes in single-cell and spatial studies of normal human skin.

Alterations observed in the corpus

• Used as a keratinocyte lineage-confirmation marker in a normal human skin atlas study profiling 297 single melanocytes from 31 donors with matched DNA/RNA sequencing and Xenium spatial validation; co-expressed with KRT14 and KRT5. No somatic alterations reported. PMID:39975212

Cancer types (linked)

• No direct cancer-type association reported in the corpus. KRT17 expression used in non-lesional skin adjacent to melanoma as a cell-type discriminator. PMID:39975212

Co-occurrence and mutual exclusivity

• Co-expressed with KRT14 and KRT5 in keratinocytes; mutually exclusive with melanocyte markers (PMEL, TYRP1, MLANA, MITF) and fibroblast markers (LUM, COL1A1, S100A4). PMID:39975212

Therapeutic relevance

• No therapeutic relevance reported in the corpus.

Open questions

• None noted in the corpus.

Sources

• PMID:39975212

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