LGR5

Overview

LGR5 (leucine-rich repeat containing G protein-coupled receptor 5) is an established Wnt/R-spondin target gene and intestinal/tissue stem cell marker. In neuroblastoma, LGR5 is identified as a component of the undifferentiated progenitor gene program that characterizes high-risk tumor cells.

Alterations observed in the corpus

  • LGR5 is over-expressed in the undifferentiated high-risk nC3 neuroblastoma cluster (FDR <0.01, Welch’s t-test), alongside MYCN, ALK, BRCA1, NTRK2, LGR5, USH2A, and migratory markers; low-risk NOR clusters do not express LGR5 at significant levels PMID:34493726.

Cancer types (linked)

  • NBL — LGR5 marks the undifferentiated, high-risk nC3 tumor cluster; its expression is enriched in tumors from older children with poor outcomes PMID:34493726.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Not directly targeted in the corpus; LGR5 presence in nC3 may reflect Wnt pathway activity in high-risk neuroblastoma progenitor-like cells PMID:34493726.

Open questions

  • Whether LGR5 is functionally required for maintenance of the undifferentiated nC3 phenotype or is merely a co-expressed marker is not addressed PMID:34493726.

Sources

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