LMCD1

Overview

LMCD1 (LIM and cysteine-rich domains 1) is a 3p-encoded gene. Its location on chromosome 3p places it in a region subject to frequent arm-level copy number loss across multiple cancer types. Studies of engineered chromosome-3p deletion have highlighted LMCD1 as a gene that exhibits paradoxical early up-regulation in cis following loss of the 3p arm, suggesting complex regulatory responses to regional genomic imbalance.

Alterations observed in the corpus

  • 3p-encoded gene up-regulated >2-fold in early-passage chr_3p-deleted AALE clones; reported in a pan-cancer aneuploidy study as a cis up-regulated locus after engineered arm-level deletion — a paradoxical expression response in the context of 3p loss. PMID:29622463

Cancer types (linked)

  • Implicated in the context of 3p arm-level deletion, which is a recurrent SCNA across multiple cancer types including lung adenocarcinoma. PMID:29622463

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic claim in the corpus.

Open questions

  • The mechanism of LMCD1 up-regulation under 3p deletion (expected to cause down-regulation) is uncharacterized; whether this represents a compensatory or confounding effect is an open question. PMID:29622463

Sources

This page was processed by entity-page-writer on 2026-05-15.