NCAM1
Overview
NCAM1 (Neural Cell Adhesion Molecule 1) is a cell surface glycoprotein involved in cell-cell adhesion and signal transduction. In small cell lung cancer (SCLC), NCAM1 serves as a neuroendocrine differentiation marker defining transcriptional subtypes.
Alterations observed in the corpus
- Neuroendocrine expression marker defining SCLC transcriptional subtypes; expressed alongside ASCL1, DLK1, CHGA, GRP, and SYP in the neuroendocrine-high subtype; expression is suppressed upon Notch pathway activation which drives transition to the non-neuroendocrine subtype PMID:26168399
- CRPC-NE-associated transcript (CD56); down-regulated by EZH2 inhibitor GSK343 in NCI-H660 PMID:26855148
Cancer types (linked)
- Small cell lung cancer (SCLC): NCAM1 is part of the neuroendocrine expression signature used to classify SCLC into transcriptional subtypes; Notch activation abrogates neuroendocrine marker expression including NCAM1 PMID:26168399
Co-occurrence and mutual exclusivity
Therapeutic relevance
- NCAM1 expression loss upon Notch activation suggests its utility as a biomarker for NOTCH pathway agonism strategies in SCLC; the paper identifies Notch-pathway agonism as a candidate therapeutic strategy PMID:26168399
Open questions
- Whether NCAM1 is a passive marker or a functional contributor to the neuroendocrine SCLC phenotype is not addressed; clinically tractable Notch-activating agents and patient-selection biomarkers using NCAM1 remain to be defined PMID:26168399
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:26855148
This page was processed by wiki-cli on 2026-05-14.