NEGR1

Overview

NEGR1 (Neuronal Growth Regulator 1) encodes an immunoglobulin superfamily cell-adhesion molecule expressed predominantly in the nervous system. In cancer genomics, NEGR1 has been flagged in focal-deletion and pathway analyses in clear cell renal cell carcinoma.

Alterations observed in the corpus

• Highlighted as a downstream pathway and SCNA feature in TieDIE / focal-deletion analyses of ccRCC (TCGA 450-case multi-platform dataset) PMID:23792563

Cancer types (linked)

• Clear cell renal cell carcinoma (ccRCC): focal deletion identified in TCGA analysis PMID:23792563

Co-occurrence and mutual exclusivity

• Co-listed with CTNNB1, TGFBR2, QKI, CADM2, PTPRD, and NRXN3 as focal-deletion features in ccRCC pathway analysis PMID:23792563

Therapeutic relevance

• No direct therapeutic nominations in the corpus.

Open questions

• The precise mechanism by which NEGR1 deletion contributes to ccRCC biology remains undefined.

Sources

• PMID:23792563

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