NRXN3

Overview

NRXN3 (Neurexin 3) encodes a presynaptic cell-adhesion molecule belonging to the neurexin family. In cancer genomics, NRXN3 has been identified as a focal deletion target in clear cell renal cell carcinoma.

Alterations observed in the corpus

Highlighted as a downstream pathway and SCNA feature in TieDIE / focal-deletion analyses of ccRCC (TCGA 450-case multi-platform dataset) PMID:23792563

Cancer types (linked)

Clear cell renal cell carcinoma (ccRCC): focal deletion identified in TCGA analysis PMID:23792563

Co-occurrence and mutual exclusivity

Co-listed with CTNNB1, TGFBR2, NEGR1, QKI, CADM2, PTPRD in focal-deletion analyses of ccRCC PMID:23792563

Therapeutic relevance

No direct therapeutic nominations in the corpus.

Open questions

Role of NRXN3 focal deletion in ccRCC pathogenesis is undefined.

Sources

PMID:23792563

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