PLXNB1

Overview

PLXNB1 (Plexin B1) encodes a transmembrane receptor for semaphorin ligands involved in axon guidance, cell migration, and cytoskeletal organization via Rho GTPase signaling. In cancer, plexin family members have been implicated in both tumor-suppressive and pro-invasive contexts depending on cancer type and ligand. Somatic mutations in PLXNB1 have been identified in adenoid cystic carcinoma (ACC), where axon-guidance pathway alterations appear to be a recurrent theme.

Alterations observed in the corpus

  • Recurrent somatic mutation in 2/25 ACC tumors (WGS cohort); part of the axon-guidance alteration cluster alongside PLXNA1, PRKD1, and Rho-pathway genes PMID:26862087

Cancer types (linked)

  • ACYC (adenoid cystic carcinoma): Recurrent axon-guidance pathway mutations (2 tumors) in a 25-sample WGS study; the broader axon-guidance mutation cluster (including SLIT1, SRGAP2, SRGAP3, SEMA3G) was identified as a novel recurrent pathway in ACC PMID:26862087

Co-occurrence and mutual exclusivity

  • Co-occurs with other axon-guidance pathway mutations (PLXNA1, PRKD1, RHOA, ARHGEF3/5/18) in ACC PMID:26862087

Therapeutic relevance

  • No direct therapeutic data in this corpus; axon-guidance pathway as a whole is newly nominated as a candidate pathway in ACC PMID:26862087

Open questions

  • Whether PLXNB1 mutations are functional drivers or passengers in ACC remains to be determined.

Sources

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