SEMA3G
Overview
SEMA3G (Semaphorin 3G) is a member of the class 3 semaphorin family of secreted axon-guidance molecules that signal through neuropilin and plexin receptors. Semaphorins regulate neuronal pathfinding and have been implicated in tumor cell migration and invasion. In adenoid cystic carcinoma (ACC), SEMA3G mutations are part of a broader pattern of axon-guidance pathway disruption that may underlie the tumor’s propensity for perineural invasion.
Alterations observed in the corpus
- SEMA3G single-tumor somatic mutation detected in adenoid cystic carcinoma (ACC) of the salivary gland as part of a recurrently disrupted axon-guidance pathway (56% of tumors in the cohort) PMID:26862087
Cancer types (linked)
- Adenoid cystic carcinoma (ACC): SEMA3G mutation part of broader axon-guidance pathway disruption present in 56% of tumors; hypothesized to contribute to perineural invasion PMID:26862087
Co-occurrence and mutual exclusivity
Therapeutic relevance
- Axon-guidance pathway disruption in ACC has been flagged as a candidate therapeutic strategy, leveraging Slit/Robo pathway exploration; no functional data specific to SEMA3G PMID:26862087
Open questions
- The functional consequence of SEMA3G mutation in ACC and its specific contribution to perineural invasion remain uncharacterized PMID:26862087
Sources
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