SLIT1
Overview
SLIT1 (Slit Guidance Ligand 1) is a secreted axon-guidance protein that signals through Roundabout (ROBO) receptors to regulate neuronal migration and axon pathfinding. SLIT-ROBO signaling has tumor-suppressive roles in some contexts, and SLIT1 has been reported as silenced or mutated in multiple cancer types. In adenoid cystic carcinoma (ACC), SLIT1 mutation is part of a recurrently disrupted axon-guidance pathway hypothesized to facilitate perineural invasion.
Alterations observed in the corpus
- SLIT1 single-tumor somatic mutation detected in adenoid cystic carcinoma (ACC) of the salivary gland as part of a recurrently disrupted axon-guidance pathway (56% of tumors in the cohort) PMID:26862087
Cancer types (linked)
- Adenoid cystic carcinoma (ACC): SLIT1 mutation part of broader axon-guidance pathway disruption present in 56% of tumors; hypothesized to contribute to perineural invasion PMID:26862087
Co-occurrence and mutual exclusivity
Therapeutic relevance
- Slit/Robo pathway exploration is flagged as a candidate therapeutic strategy for ACC; no clinical data yet PMID:26862087
Open questions
- Whether SLIT1 mutation in ACC is functionally relevant to Robo-mediated tumor invasion or is a passenger event remains unresolved PMID:26862087
Sources
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