PTPRG
Overview
PTPRG (Protein Tyrosine Phosphatase Receptor Type G) encodes a receptor-type phosphatase with established tumor-suppressor functions. In adenoid cystic carcinoma (ACC), PTPRG harbors nonsense mutations in the phosphatase domain.
Alterations observed in the corpus
- Nonsense E736* mutation in the phosphatase domain observed in ACC; classified as a tyrosine phosphatase tumor suppressor PMID:23685749
Cancer types (linked)
- Adenoid cystic carcinoma (ACC): nonsense mutation in phosphatase domain PMID:23685749
Co-occurrence and mutual exclusivity
- Co-occurs with other receptor tyrosine phosphatase tumor suppressors (PTPRH, PTPRJ, PTPRK) recurrently mutated in ACC PMID:23685749
Therapeutic relevance
- No direct therapeutic nominations in the corpus.
Open questions
- Whether PTPRG loss contributes functionally to the PI3K/FGF/IGF axis activation in ACC is unknown.
Sources
This page was processed by crosslinker on 2026-05-09.