PTPRJ
Overview
PTPRJ (Protein Tyrosine Phosphatase Receptor Type J) encodes a receptor-type phosphatase with established tumor-suppressor functions. In adenoid cystic carcinoma (ACC), PTPRJ harbors missense mutations.
Alterations observed in the corpus
- Missense mutation observed in ACC; classified as a tyrosine phosphatase tumor suppressor PMID:23685749
Cancer types (linked)
- Adenoid cystic carcinoma (ACC): missense mutation PMID:23685749
Co-occurrence and mutual exclusivity
- Co-occurs with other receptor tyrosine phosphatase tumor suppressors (PTPRG, PTPRH, PTPRK) recurrently mutated in ACC PMID:23685749
Therapeutic relevance
- No direct therapeutic nominations in the corpus.
Open questions
- Whether PTPRJ missense mutations are loss-of-function and contribute to PI3K/AKT pathway activation in ACC is unknown.
Sources
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