PTPRH
Overview
PTPRH (Protein Tyrosine Phosphatase Receptor Type H) encodes a receptor-type phosphatase with tumor-suppressor functions. In adenoid cystic carcinoma (ACC), PTPRH harbors a nonsense mutation truncating the phosphatase domain.
Alterations observed in the corpus
- Nonsense W602* mutation observed in ACC; classified as a tyrosine phosphatase tumor suppressor PMID:23685749
Cancer types (linked)
- Adenoid cystic carcinoma (ACC): nonsense truncating mutation PMID:23685749
Co-occurrence and mutual exclusivity
- Co-occurs with other receptor tyrosine phosphatase tumor suppressors (PTPRG, PTPRJ, PTPRK) recurrently mutated in ACC PMID:23685749
Therapeutic relevance
- No direct therapeutic nominations in the corpus.
Open questions
- Functional consequence of W602* truncation for PTPRH phosphatase activity and downstream signaling in ACC is uncharacterized.
Sources
This page was processed by crosslinker on 2026-05-09.