TBX21

Overview

TBX21 (T-bet) is a master Th1 transcription factor included in the 20-gene ICR immune signature.

Alterations observed in the corpus

  • TBX21 is a component of the 20-gene Immunologic Constant of Rejection (ICR) panel (Th1 signaling genes) used to stratify colon cancer immune subtypes PMID:37202560.

Cancer types (linked)

  • COAD — ICR panel component contributing to ICR-high vs ICR-low prognostic stratification PMID:37202560.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct targeted therapy reported in the corpus; ICR module may have predictive utility for immunotherapy PMID:37202560.

Open questions

  • None specific to TBX21 in the corpus.

Sources

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