IRF1
Overview
IRF1 is an interferon regulatory transcription factor central to Th1/IFNγ signaling. In the corpus it is a component of the 20-gene Immunologic Constant of Rejection (ICR) immune signature.
Alterations observed in the corpus
- No somatic alteration claims; IRF1 is used as an expression component of the ICR immune-classification signature PMID:37202560.
Cancer types (linked)
- COAD — IRF1 expression contributes to the ICR signature that outperforms CMS and MSI classifications for prognosis in primary colon cancer (n=348) PMID:37202560.
Co-occurrence and mutual exclusivity
Therapeutic relevance
- ICR-high status (including IRF1) correlates with immunotherapy response in other tumor types referenced by the authors; not directly tested in colon cancer PMID:37202560.
Open questions
- Whether IRF1 expression alone adds prognostic value beyond the composite ICR signature is not addressed PMID:37202560.
Sources
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