ALDOC

Overview

ALDOC (aldolase C) is a glycolytic enzyme expressed predominantly in astrocytes and Bergmann glia in the normal brain. In oligodendroglioma it marks the differentiated astro-like tumor cell compartment, serving as a lineage-of-origin indicator within the developmental hierarchy inferred from single-cell transcriptomics.

Alterations observed in the corpus

• ALDOC (together with APOE, SOX9, and GFAP) marks the differentiated astro-like compartment in grade II IDH-mutant 1p/19q-codeleted oligodendroglioma; identified from scRNA-seq of 4,347 cells across 6 tumors PMID:27806376.

Cancer types (linked)

• ODG — ALDOC expression defines the astro-like differentiated sub-population in oligodendroglioma; these cells are largely non-cycling and distinct from the proliferative stem/progenitor compartment PMID:27806376.

Co-occurrence and mutual exclusivity

• ALDOC co-expresses with APOE, SOX9, and GFAP in astro-like tumor cells; mutually exclusive with the stem/progenitor program (ASCL1, CHD7, CCND2) and the oligo-like program (OLIG1, OLIG2) PMID:27806376.

Therapeutic relevance

• Not directly therapeutically targeted in the corpus; the astro-like ALDOC-high cells are largely non-cycling and thus unlikely to fuel long-term tumor growth PMID:27806376.

Open questions

• Whether the astro-like program in oligodendroglioma reflects a genuine normal astrocytic identity or an aberrant transdifferentiation is not resolved in the corpus.

Sources

• PMID:27806376

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