CHD7
Overview
CHD7 (chromodomain helicase DNA-binding protein 7) is an ATP-dependent chromatin remodeling factor essential for neural stem/progenitor cell maintenance and development. In oligodendroglioma, CHD7 is a component of the stem/progenitor transcriptional program, consistent with its known role in maintaining neural progenitor identity.
Alterations observed in the corpus
- CHD7 is part of the stem/progenitor transcriptional program in grade II IDH-mutant 1p/19q-codeleted oligodendroglioma, co-expressed with SOX2, SOX4, SOX11, NFIB, ASCL1, CD24, BOC, TCF4, and CCND2; identified from scRNA-seq of 4,347 cells across 6 tumors PMID:27806376.
- Identified as recurrently mutated in medulloblastoma (5/37 tumors, 14%), implicating chromatin remodeling pathways in pediatric brain cancer PMID:22722829
- Additional recurrently altered candidate driver in medulloblastoma, stratified across subgroups in oncoprint analyses of the ICGC/CBTTC cohort (n=491) PMID:28726821.
Cancer types (linked)
- ODG — CHD7 marks the proliferative stem/progenitor apex of grade II oligodendroglioma; this compartment is enriched for cycling cells (1.5–8% MKI67+) and closely resembles a tri-potent neural progenitor rather than an OPC PMID:27806376.
Co-occurrence and mutual exclusivity
Therapeutic relevance
- The stem/progenitor program (including CHD7) defines the small cycling sub-population considered the most plausible therapeutic target in oligodendroglioma; therapies targeting OPC biology may miss this proliferative apex PMID:27806376.
Open questions
- Whether CHD7 chromatin remodeling activity is required for maintenance of the oligodendroglioma stem/progenitor state, and whether CHD7 inhibition could deplete this compartment, is not tested in the corpus.
Sources
This page was processed by crosslinker on 2026-05-04. - PMID:22722829
This page was processed by wiki-cli on 2026-05-06. - PMID:28726821
This page was processed by wiki-cli on 2026-05-15.