GNLY

Overview

GNLY encodes granulysin, a cytolytic effector released by CD8 T cells and NK cells.

Alterations observed in the corpus

  • Effector cytotoxic component of the 20-gene Immunologic Constant of Rejection (ICR) signature used to stratify colon cancer immune subtypes PMID:37202560.

Cancer types (linked)

  • COAD — expressed as part of the prognostic ICR module in the AC-ICAM cohort PMID:37202560.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Contributes to the ICR score, which outperformed CMS and MSI for prognosis and may have predictive utility for immunotherapy response PMID:37202560.

Open questions

  • None flagged in the corpus.

Sources

This page was processed by crosslinker on 2026-04-08.