PRF1

Overview

PRF1 encodes perforin, a cytotoxic effector molecule. In the corpus it is part of the ICR gene expression signature prognostic in colon cancer.

Alterations observed in the corpus

  • Effector cytotoxic component of the 20-gene ICR signature used to classify 348 primary colon cancers in the AC-ICAM cohort; no PRF1-specific mutation finding reported PMID:37202560.
  • PRF1 encodes perforin, a component of the cytolytic-activity signature (geometric mean of GZMA + PRF1); elevated expression in clinical-benefit tumors receiving ipilimumab in metastatic melanoma (P = 0.042, Mann-Whitney) PMID:26359337
  • Expression of PRF1 (perforin-1) did not significantly differ between anti-PD-1 responders and non-responders in pretreatment metastatic melanoma (n=28 RNA-seq subset); the checkpoint/effector gene panel including PRF1 was not differentially expressed in whole-tumor bulk transcriptome analysis, potentially due to dilution of immune-cell signal. PMID:26997480
  • PRF1 (perforin) geometric mean with GZMA defines the cytolytic activity score; on-therapy increases in PRF1 associated with benefit in both Ipi-N (p=0.005) and Ipi-P (p=0.043) patients treated with nivolumab for melanoma PMID:29033130

Cancer types (linked)

  • Colon adenocarcinoma (COAD) — part of ICR signature that outperforms CMS/MSI for prognosis PMID:37202560.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic link reported in the corpus.

Open questions

  • None specific to PRF1 in this cohort.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:26359337

This page was processed by crosslinker on 2026-05-14. - PMID:26997480

This page was processed by wiki-cli on 2026-05-14. - PMID:29033130

This page was processed by wiki-cli on 2026-05-15.