IL12B

Overview

IL12B encodes the p40 subunit shared by IL-12 and IL-23, key cytokines driving Th1 differentiation and cytotoxic immunity.

Alterations observed in the corpus

• Th1-signaling component of the 20-gene ICR signature used in the AC-ICAM colon cancer atlas PMID:37202560.

Cancer types (linked)

• COAD — ICR Th1 component in the AC-ICAM cohort PMID:37202560.

Co-occurrence and mutual exclusivity

• Co-expressed with IFNG, TBX21, CD8A, CD8B, STAT1, IRF1 in the ICR Th1 arm PMID:37202560.

Therapeutic relevance

• Component of the prognostic ICR module PMID:37202560.

Open questions

• None flagged in the corpus.

Sources

• PMID:37202560

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