ITPKB

Overview

ITPKB encodes inositol-trisphosphate 3-kinase B. It is a recurrent driver in classic Hodgkin lymphoma HRS cells.

Alterations observed in the corpus

  • Mutated in 28% of cHL cases; tended to carry more than one nonsynonymous mutation per case PMID:36723991.
  • Elevated noncoding:coding mutation ratio consistent with AID off-target activity PMID:36723991.
  • Novel CLL driver candidate involved in B cell receptor signaling; mutations identified in CLL WES of 160 tumors (Broad) PMID:23415222

Cancer types (linked)

  • CHL — recurrent driver in FACS-purified HRS cells across WGS+WES cohort (n=61) PMID:36723991.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • None reported.

Open questions

  • Functional consequence of multi-hit and noncoding ITPKB lesions in cHL remains to be characterized PMID:36723991.

Sources

This page was processed by crosslinker on 2026-04-08. - PMID:23415222

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