TMSB4X
Overview
TMSB4X is recurrently mutated in classic Hodgkin lymphoma via AID off-target activity.
Alterations observed in the corpus
- TMSB4X showed an elevated noncoding:coding mutation ratio in classic Hodgkin lymphoma HRS cells, consistent with AID off-target activity PMID:36723991.
Cancer types (linked)
- CHL — AID off-target mutation hotspot PMID:36723991.
Co-occurrence and mutual exclusivity
- Co-occurs among AID-target genes (BCL7A, SOCS1, IL4R, ITPKB) PMID:36723991.
Therapeutic relevance
- No direct targeted therapy reported in the corpus.
Open questions
- Functional impact of noncoding AID-driven TMSB4X mutations on cHL biology is not resolved PMID:36723991.
Sources
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