WASHC1
Overview
WASHC1 (WASH Complex Subunit 1, previously reported as WASH1) encodes a core component of the WASH actin-nucleation complex involved in endosomal sorting and recycling. It was identified as a significantly mutated gene preferentially targeted in African American (AA) colorectal cancers relative to Caucasian CRCs, suggesting a potential ethnicity-associated driver role.
Alterations observed in the corpus
- Identified as one of 20 significantly mutated genes preferentially targeted in African American CRCs (n=103 AA discovery + validation vs n=129 Caucasian); part of a 15-gene set with higher mutation frequency in AA than Caucasian CRCs PMID:25583493
Cancer types (linked)
- COADREAD — significantly mutated in African American CRCs; part of a 15-gene set accounting for 41% of AA CRCs vs 15% of Caucasian CRCs PMID:25583493
Co-occurrence and mutual exclusivity
Therapeutic relevance
- No direct drug targeting reported in this corpus; inclusion in an AA-specific CRC driver gene panel may have implications for ethnicity-stratified treatment or screening strategies PMID:25583493
Open questions
- Functional consequences of WASHC1 mutations in CRC have not been experimentally validated; the paper’s conservative selection criterion (significant in both discovery and validation cohorts) provides statistical support but does not establish mechanism PMID:25583493
Sources
This page was processed by crosslinker on 2026-05-14.