WDR87

Overview

WDR87 (WD Repeat Domain 87) is a poorly characterised WD-repeat family protein. It was identified as a significantly mutated gene preferentially targeted in African American (AA) colorectal cancers in a whole-exome and targeted sequencing study, suggesting a potential ethnicity-associated role in CRC biology.

Alterations observed in the corpus

Identified as one of 20 significantly mutated genes preferentially targeted in African American CRCs (n=103 AA, n=129 Caucasian); part of a 15-gene set with significantly higher mutation frequency in AA than Caucasian CRCs PMID:25583493

Cancer types (linked)

COADREAD — significantly mutated in African American CRCs; part of the 15-gene AA-preferential panel accounting for 41% of AA CRCs vs 15% of Caucasian CRCs PMID:25583493

Co-occurrence and mutual exclusivity

Co-identified in the same AA-specific significantly mutated gene panel alongside WASHC1, ZNF717, ZNF862, EPHA6, FLCN, and others PMID:25583493

Therapeutic relevance

No drug targeting reported; biological function in CRC remains to be characterised PMID:25583493

Open questions

Functional consequences of WDR87 mutations in CRC have not been experimentally validated in this study; mechanism of action unknown PMID:25583493

Sources

PMID:25583493

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