ZNF862

Overview

ZNF862 (Zinc Finger Protein 862) is a zinc-finger family member of largely unknown function. It was identified as one of 20 significantly mutated genes preferentially targeted in African American (AA) colorectal cancers compared to Caucasian CRCs, placing it in a candidate list of ethnicity-associated CRC drivers.

Alterations observed in the corpus

Identified as one of 20 significantly mutated genes preferentially targeted in African American CRCs (n=103 AA discovery + validation vs n=129 Caucasian); part of a 15-gene set with significantly higher mutation frequency in AA than Caucasian CRCs PMID:25583493

Cancer types (linked)

COADREAD — significantly mutated in African American CRCs; part of the 15-gene AA-preferential panel accounting for 41% of AA CRCs vs 15% of Caucasian CRCs PMID:25583493

Co-occurrence and mutual exclusivity

Co-identified in the same AA-specific significantly mutated gene panel alongside ZNF717, WASHC1, WDR87, EPHA6, FLCN, and others PMID:25583493

Therapeutic relevance

No drug targeting reported; biological function in CRC remains to be characterised PMID:25583493

Open questions

Functional consequences of ZNF862 mutations in CRC have not been experimentally validated; molecular mechanism linking ZNF862 loss to colorectal tumourigenesis is unknown PMID:25583493

Sources

PMID:25583493

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