BOC

Overview

BOC (brother of CDO) is a cell surface receptor and co-receptor for hedgehog signaling ligands, expressed during neural development. In oligodendroglioma it is a component of the stem/progenitor transcriptional program identified by single-cell transcriptomics.

Alterations observed in the corpus

  • BOC is part of the stem/progenitor transcriptional program in grade II IDH-mutant 1p/19q-codeleted oligodendroglioma, co-expressed with SOX2, SOX4, SOX11, NFIB, ASCL1, CHD7, CD24, TCF4, and CCND2; identified from scRNA-seq of 4,347 cells across 6 tumors PMID:27806376.

Cancer types (linked)

  • ODG — BOC marks the proliferative stem/progenitor apex of oligodendroglioma; this compartment is enriched for cycling cells (MKI67+, 1.5–8% of all cells) and most closely resembles a tri-potent neural progenitor PMID:27806376.

Co-occurrence and mutual exclusivity

  • Co-expresses with ASCL1, CHD7, CCND2, CD24, and SOX family transcription factors in the stem/progenitor compartment; mutually exclusive with the astro-like (ALDOC, APOE) and oligo-like (OLIG1) differentiation programs PMID:27806376.

Therapeutic relevance

  • The stem/progenitor program (including BOC) defines the small cycling sub-population considered the most plausible therapeutic target in oligodendroglioma PMID:27806376.

Open questions

  • Whether BOC-mediated hedgehog co-receptor activity contributes functionally to maintenance of the oligodendroglioma stem/progenitor state is not tested in the corpus.

Sources

This page was processed by crosslinker on 2026-05-04.