CD24

Overview

CD24 is a GPI-anchored cell surface glycoprotein expressed on neural progenitors, B cells, and multiple tumor types. In oligodendroglioma, it is a component of the stem/progenitor transcriptional program identified by single-cell transcriptomics, co-expressed with other neural progenitor markers.

Alterations observed in the corpus

  • CD24 is part of the stem/progenitor transcriptional program in grade II IDH-mutant 1p/19q-codeleted oligodendroglioma, co-expressed with SOX2, SOX4, SOX11, NFIB, ASCL1, CHD7, BOC, TCF4, and CCND2; identified from scRNA-seq of 4,347 cells across 6 tumors PMID:27806376.

Cancer types (linked)

  • ODG — CD24 marks the proliferative stem/progenitor apex of oligodendroglioma; this compartment is enriched for cycling cells (MKI67+, 1.5–8% of all cells) and is a plausible therapeutic target PMID:27806376.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • The stem/progenitor program (including CD24) defines the small cycling sub-population considered the most plausible therapeutic target in oligodendroglioma PMID:27806376.

Open questions

  • CD24 as a potential cell-surface target for antibody-based or CAR-T approaches in oligodendroglioma has not been evaluated in the corpus.

Sources

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