IFITM1

Overview

IFITM1 (Interferon-Induced Transmembrane Protein 1) is an interferon-stimulated gene that restricts viral entry. In HGSOC precursor lesions, IFITM1 is among the earliest upregulated IFN-response genes, induced even at the fimbriae stage.

Alterations observed in the corpus

• IFITM1 is an IFN-stimulated gene upregulated early in HGSOC development; induced even at the fimbriae stage, making it one of the earliest markers of IFN pathway activation in fallopian tube epithelium PMID:39386723.
• Part of a coordinated IFN-alpha and IFN-gamma pathway gene upregulation including STAT1, IRF7, IRF9, ISG15, TAP1, and HLA-A beginning at the p53 signature stage and persisting through STIC and invasive HGSOC PMID:39386723.

Cancer types (linked)

• HGSOC — upregulated at the p53 signature and STIC stages as part of early IFN activation; studied in 44 FFPE fallopian tube specimens from 43 individuals using GeoMx spatial transcriptomics PMID:39386723.

Co-occurrence and mutual exclusivity

• Co-upregulated with HLA-A, HLA-E, IRF7, IRF9, ISG15, STAT1, MX1, TAP1 in the IFN response program of HGSOC precursors PMID:39386723.

Therapeutic relevance

• Early IFITM1 induction in precursor lesions suggests it could serve as a biomarker for IFN pathway activation in HGSOC risk stratification PMID:39386723.

Open questions

• Whether IFITM1 expression in fimbriae epithelium is triggered by micronuclear rupture or other cGAS-STING-independent mechanisms is unresolved PMID:39386723.

Sources

• PMID:39386723

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