IRF7

Overview

IRF7 (Interferon Regulatory Factor 7) is a master transcriptional regulator of type I IFN responses. In HGSOC precursor lesions, IRF7 is among the IFN-stimulated genes activated early in the carcinogenic progression.

Alterations observed in the corpus

  • IRF7 is an IFN-stimulated gene upregulated early in HGSOC development beginning at the p53 signature stage; part of an IFN-alpha and IFN-gamma pathway gene upregulation program also including STAT1, IFITM1, IRF9, ISG15, TAP1, and HLA-A PMID:39386723.

Cancer types (linked)

  • HGSOC — upregulated in fallopian tube precursor lesions (p53 signatures, STICs) and invasive cancer; studied by GeoMx spatial transcriptomics on 44 specimens from 43 individuals PMID:39386723.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Early IFN pathway activation including IRF7 in HGSOC precursors could serve as a biomarker panel for risk stratification of high-risk patients PMID:39386723.

Open questions

  • The relationship between chronic IFN activation (including IRF7 upregulation), IRDS gene signature emergence, and clinical chemoresistance in HGSOC is correlative and requires prospective investigation PMID:39386723.

Sources

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