IRF9

Overview

IRF9 (Interferon Regulatory Factor 9) is a transcription factor that forms the ISGF3 complex with STAT1 and STAT2 to mediate type I IFN signaling. In HGSOC, IRF9 is part of the early IFN pathway activation in precursor lesions.

Alterations observed in the corpus

  • IRF9 is an IFN-stimulated gene upregulated early in HGSOC development beginning at the p53 signature stage; part of an IFN-alpha and IFN-gamma pathway gene upregulation program also including STAT1, IFITM1, IRF7, ISG15, TAP1, and HLA-A PMID:39386723.

Cancer types (linked)

  • HGSOC — upregulated in fallopian tube precursor lesions (p53 signatures, STICs) and invasive cancer; studied by GeoMx spatial transcriptomics on 44 specimens from 43 individuals PMID:39386723.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Early IFN pathway activation including IRF9 in HGSOC precursors could serve as a biomarker panel for risk stratification of high-risk patients PMID:39386723.

Open questions

  • The relationship between chronic IFN activation (including IRF9 upregulation), IRDS gene signature emergence, and clinical chemoresistance in HGSOC is correlative and requires prospective investigation PMID:39386723.

Sources

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