CHD3

Overview

CHD3 (chromodomain helicase DNA binding protein 3) is a component of the NuRD chromatin remodeling complex. It has been newly nominated as a significantly mutated gene in papillary renal cell carcinoma through comprehensive non-clear-cell RCC genomic analysis.

Alterations observed in the corpus

• Newly nominated significantly mutated gene in pRCC by multi-method driver analysis in the non-clear-cell RCC genomic cohort PMID:25401301
• p.Gln660His in the second chromodomain (PolyPhen2=0.99) and p.Ser230Leu in the first PHD repressive-mark reader in CTCL; encodes a NuRD chromatin remodeling complex component PMID:26551667

Cancer types (linked)

• PRCC: CHD3 identified as a recurrently mutated chromatin remodeling gene in papillary renal cell carcinoma PMID:25401301

Co-occurrence and mutual exclusivity

• Nominated alongside NF2, SLC5A3, PNKD, CPQ, LRP2, NHERF1, SETD2, and CRTC1 as new significantly mutated genes in pRCC PMID:25401301

Therapeutic relevance

• No direct therapeutic relevance established in pRCC; NuRD complex disruption may have implications for chromatin-targeted therapies PMID:25401301

Open questions

• Oncogenic vs passenger status for CHD3 in pRCC lacks functional characterization PMID:25401301

Sources

• PMID:25401301

This page was processed by crosslinker on 2026-05-14. - PMID:26551667

This page was processed by crosslinker on 2026-05-14.